TRPC6 COUNTERACTS TRPC3-NOX2 PROTEIN COMPLEX LEADING TO ATTENUATION OF HYPERGLYCEMIA-INDUCED HEART FAILURE IN MICE

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

Abstract Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure.We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive cardiac fibrosis by forming stably functional complex with NADPH oxidase 2 (Nox2).Although TR

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THE ORIGIN OF THE CIVIL LAW CODIFICATION IN EUROPE

Codification represents the regulation of a certain field (branch) of law by a comprehensive law called the Code (the Civil Code, Criminal Code, etc.).The success of codification depends on two Accessories very important conditions: the first one refers to the existence of a dedicated authority, and the second one concerns its implementation in a g

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Thirty years of ground deformation monitoring at Stromboli volcano

Abstract Since 1992, INGV has collected tilt, GNSS (Global Navigation Satellite System) and strainmeter data, for the monitoring of effusive and explosive activity of Stromboli volcano.In this timespan, ground deformations related to eruptive activity, Vanity Stool paroxystic explosions, cycles of inflation/deflation and many other phenomena of vol

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